ODAD4

Cilia effects upon perturbation of ODAD4

Loss-of-function effect:

Shorter cilia

Phenotypes

Human ciliopathy phenotype:

primary ciliary dyskinesia

Ciliopathy associations

• Primary Ciliary Dyskinesia

Subcellular localization

basal body, cilia, flagella, transition zone

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Transition zone

Function

Member of the ODA-docking complex in humans and mice. Plays an essential role in the correct function of motile cilia and is therefore important for the development of left-right patterning. Mutations result in PCD and randomisation of left-right body asymmetry. TTC25 deficiency in mice leads to absence of ODA (27486780). May interacts with CFAP53 to facilitate ODA proteins transport into the axoneme and regulate its stable docking with the axonemal (33347437). TTC25 morphant cells show fewer and extremely shorter cilia. (17961536).