ODF1

outer dense fiber of sperm tails 1

Ensembl:
ENSG00000155087
UniProt:
Q14990
OMIM:
182878
Synonyms:
CT133, HSPB10, ODF27, ODFPG, RT7

Cilia effects upon perturbation of ODF1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.00) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating phosphate level, increased circulating iron level
Mouse ciliopathy phenotype:
male infertility

Ciliopathy associations

  • Male Infertility

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm

Function

CCDC42 co-localizes with ODF1, when both proteins are ectopically expressed in NIH3T3 cells, at the centrosome. CCDC42 interacts with ODF1 and ODF2 in the formation of the male germ cell cytoskeleton(31475146).

Model organism evidence

Mus musculus (1 reference)

Outer dense fibers stabilize the axoneme to maintain sperm motility.

PMIDs: 29168316