ODF1

outer dense fiber of sperm tails 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000155087
UniProt:
Q14990
OMIM:
182878
Synonyms:
CT133, HSPB10, ODF27, ODFPG, RT7

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.00) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating phosphate level, increased circulating iron level

Ciliopathy associations

  • Male Infertility

References: PMID:35207567

Subcellular localization

basal body, nucleus

References: PMID:31475146

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm

Function

CCDC42 co-localizes with ODF1, when both proteins are ectopically expressed in NIH3T3 cells, at the centrosome. CCDC42 interacts with ODF1 and ODF2 in the formation of the male germ cell cytoskeleton(31475146).