ODF2

Cilia effects upon perturbation of ODF2

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Overexpression effect:

No effect

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

• Male Infertility

References: PMID:35207567

Subcellular localization

basal body, centrosome, cytosol, nucleus, cilia

References: PMID:41410385, PMID:41005307, PMID:15852003, PMID:30623524, PMID:22265411

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Reproduction & sperm
• Protein processing & maturation

Function

Required for localization of ninein to the appendages of the mother centriole, for the formation of the appendages necessary for primary cilia formation, as it to appears to originate from the Odf2- positive end (15852003). It associates with Cep128 in the construction of subdistal appendages (30623524). Critical in the formation of basal feet, important for the polarization of basal bodies and coordinated beating of cilia (22265411).