ODF4
outer dense fiber of sperm tails 4
- Ensembl:
- ENSG00000184650
- UniProt:
- Q2M2E3
- OMIM:
- 610097
- Synonyms:
- CT136, OPPO1
Cilia effects upon perturbation of ODF4
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=712, lfc=-1.42) PMID:30270045
Phenotypes
- Mouse ciliopathy phenotype:
- abnormal uriry bladder morphology, enlarged heart, male infertility
Subcellular localization
flagella
Functional category
- Reproduction & sperm
Function
ODF4 has localized in flagella.
Model organism evidence
Mus musculus (2 references)
RESULTS: In in vitro condition, Odf4 -/- spermatozoa with hairpin flagella harboring large cytoplasmic droplets (CDs) underwent capacitation, about 30% of large CDs were removed from spermatozoa, and the flagella became straight (capacitation test).
The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.