ODF4

outer dense fiber of sperm tails 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000184650
UniProt:
Q2M2E3
OMIM:
610097
Synonyms:
CT136, OPPO1

Cilia effects upon perturbation of ODF4

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=712, lfc=-1.42) PMID:30270045

Subcellular localization

flagella

References: PMID:25613900

Functional category

  • Reproduction & sperm

Function

ODF4 has localized in flagella.