ONECUT1

one cut homeobox 1

Ensembl:
ENSG00000169856
UniProt:
Q9UBC0
OMIM:
604164
Synonyms:
HNF-6, HNF6, HNF6A

Cilia effects upon perturbation of ONECUT1

Loss-of-function effect:
Abnormal / altered cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Also called HNF6. Transcription factor that controls the expression of a network of genes involved in ciliogenesis, cilium function and in hereditary polycystic diseases (16472605).