OPN1LW

opsin 1, long wave sensitive

Ensembl:
ENSG00000102076
UniProt:
P04000
OMIM:
300822
Synonyms:
CBBM, CBP, COD5, RCP

Cilia effects upon perturbation of OPN1LW

Ciliogenesis screen results (3 screens)

  • Kim2016: Not Reported
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Encodes photoreceptor opsins and is associated with blue cone monochromacy (30614359). Requires IFT20 for localisation (21307337).

Model organism evidence

Mus musculus (1 reference)

Structural analysis revealed that aged cones in both models displayed degenerative changes, including mislocalized mitochondria and compromised connecting cilia.

PMIDs: 40297680