OPN1MW

opsin 1, medium wave sensitive

Ensembl:
ENSG00000268221
UniProt:
P04001
OMIM:
300821
Synonyms:
CBBM, CBD, COD5, GCP, OPN1MW1

Cilia effects upon perturbation of OPN1MW

Ciliogenesis screen results (3 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.84) PMID:26167766
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Encodes photoreceptor opsins and is associated with blue cone monochromacy (30614359). Requires IFT20 for localisation (21307337).

Model organism evidence

Mus musculus (1 reference)

Structural analysis revealed that aged cones in both models displayed degenerative changes, including mislocalized mitochondria and compromised connecting cilia.

PMIDs: 40297680