OPN1SW

opsin 1, short wave sensitive

Ensembl:
ENSG00000128617
UniProt:
P03999
OMIM:
613522
Synonyms:
BCP, BOP, CBT

Cilia effects upon perturbation of OPN1SW

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.86) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Encodes photoreceptor opsins and is associated with blue cone monochromacy (30614359). Requires IFT20 for localisation (21307337).

Model organism evidence

Mus musculus (1 reference)

Structural analysis revealed that aged cones in both models displayed degenerative changes, including mislocalized mitochondria and compromised connecting cilia.

PMIDs: 40297680