OPRL1

Cilia effects upon perturbation of OPRL1

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.89) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal skin morphology, decreased mean corpuscular hemoglobin, enlarged spleen, small liver, abnormal eye morphology, increased mean platelet volume, increased red blood cell distribution width

Mouse ciliopathy phenotype:

abnormal vitreous body morphology, microphthalmia, cataract

Subcellular localization

basal body, lysosomes

Functional category

• Ciliary assembly/disassembly
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Neuro l ciliary GPCR. As a GPCR, it may play sensory or sig lling roles in the ciliary vesicle at early stages of ciliogenesis