OPRL1

opioid related nociceptin receptor 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000125510
UniProt:
P41146
OMIM:
602548
Synonyms:
KOR-3, NOCIR, NOPR, OOR, ORL1, PNOCR

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.89) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal skin morphology, decreased mean corpuscular hemoglobin, enlarged spleen, small liver, abnormal eye morphology, increased mean platelet volume, increased red blood cell distribution width

Subcellular localization

basal body, lysosomes, ciliary tip

References: PMID:41005307, PMID:26167768

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Neuronal ciliary GPCR. As a GPCR, it may play sensory or signalling roles in the ciliary vesicle at early stages of ciliogenesis