OPRM1
opioid receptor mu 1
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000112038
- UniProt:
- P35372
- OMIM:
- 600018
- Synonyms:
- MOR, MOR1, MOP, OPRM, LMOR
Subcellular localization
cilia
References: PMID:38678559
Functional category
- Signaling (Hedgehog, GPCRs, ion channels)
Function
OPRM1 encodes the mu opioid receptor (MOR), a G protein-coupled receptor of the central nervous system that mediates pain relief, reward and dependence. MOR is selectively targeted to primary cilia of neurons (Fagan et al., 2024, Cell Rep, PMID 38678559).