ORC4

origin recognition complex subunit 4

Ensembl:
ENSG00000115947
UniProt:
O43929
OMIM:
603056
Synonyms:
HSORC4, ORC4L, ORC4P

Cilia effects upon perturbation of ORC4

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
abnormal tail movements

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Reproduction & sperm

Function

Depletion of ORC1, ORC4, ORC6, CDT1 and CDC6 resulted in dramatically impaired cilia formation similar to ORC1-deficient patient cells ( 23516378).

Model organism evidence

Danio rerio (1 reference)

Loss-of-function of Orc4 and Orc6, respectively, conferred similar ciliopathy phenotypes and cilium shortening in zebrafish, suggesting that several, if not all, components of the ORC regulate ciliogenesis downstream to or in addition to their canonical function in replication initiation.

PMIDs: 30696958