ORC4

origin recognition complex subunit 4

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000115947
UniProt:: O43929
OMIM:: 603056
Synonyms:: HSORC4, ORC4L, ORC4P

Cilia effects upon perturbation of ORC4

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal tail movements

Subcellular localization

nucleus

References: PMID:23516378

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
Reproduction & sperm

Function

Depletion of ORC1, ORC4, ORC6, CDT1 and CDC6 resulted in dramatically impaired cilia formation similar to ORC1-deficient patient cells ( 23516378).

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