ORC6

Cilia effects upon perturbation of ORC6

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.75) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.45) PMID:41160700

Phenotypes

Mouse phenotype:

embryonic lethality prior to organogenesis, impaired pupillary reflex, preweaning lethality, complete penetrance, decreased circulating creatinine level, hyperactivity

Subcellular localization

nucleus

References: PMID:23516378

Functional category

• Ciliary assembly/disassembly

Function

Depletion of ORC1, ORC4, ORC6, CDT1 and CDC6 resulted in dramatically impaired cilia formation similar to ORC1-deficient patient cells ( 23516378).