ORC6

origin recognition complex subunit 6

Ensembl:
ENSG00000091651
UniProt:
Q9Y5N6
OMIM:
607213
Synonyms:
ORC6L

Cilia effects upon perturbation of ORC6

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.75) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.45) PMID:41160700

Phenotypes

Mouse phenotype:
embryonic lethality prior to organogenesis, impaired pupillary reflex, preweaning lethality, complete penetrance, decreased circulating creatinine level, hyperactivity
Mouse ciliopathy phenotype:
persistence of hyaloid vascular system

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology

Function

Depletion of ORC1, ORC4, ORC6, CDT1 and CDC6 resulted in dramatically impaired cilia formation similar to ORC1-deficient patient cells ( 23516378).

Model organism evidence

Danio rerio (1 reference)

Loss-of-function of Orc4 and Orc6, respectively, conferred similar ciliopathy phenotypes and cilium shortening in zebrafish, suggesting that several, if not all, components of the ORC regulate ciliogenesis downstream to or in addition to their canonical function in replication initiation.

PMIDs: 30696958