OSBPL10

oxysterol binding protein like 10

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000144645
UniProt:
Q9BXB5
OMIM:
606738

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

References: doi:10.1101/2025.05.11.653368

Functional category

  • Ciliary assembly/disassembly

Function

Myoferlin (MYOF) and Oxysterol Binding Protein Like 10 (OSBPL10) were detected at the basal body, and NRP1 was localized along the ciliary shaft. Detected in primary cilia of human hypothalamic neurons by proximity proteomics (Macarelli et al., 2025, bioRxiv, doi 10.1101/2025.05.11.653368).