OTUB1

OTU deubiquitinase, ubiquitin aldehyde binding 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000167770
OMIM:: 608337
Synonyms:: FLJ20113, FLJ40710

Phenotypes

Mouse phenotype:: abnormal cranium morphology

Subcellular localization

Cytosol, Cytoplasmic bodies

References: PMID:39785769

Functional category

Trafficking (BBSome
small GTPases
vesicular transport
ATPases)

Function

OTUB1 interacts with and deubiquitinates RAB8A, reducing K48-linked ubiquitination and stabilizing RAB8A protein levels, suggesting a potential regulatory role in RAB8A-dependent ciliary trafficking pathways(39785769).

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