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Phenotypes

Mouse phenotype:

abnormal cranium morphology

Subcellular localization

Ciliary associated gene, Cytosol, Cytoplasmic bodies

Functional category

• Trafficking (BBSome
• small GTPases
• vesicular transport
• ATPases)

Function

OTUB1 interacts with and deubiquitinates RAB8A, reducing K48-linked ubiquitination and stabilizing RAB8A protein levels, suggesting a potential regulatory role in RAB8A-dependent ciliary trafficking pathways(39785769).