P2RX2

purinergic receptor P2X 2

Ensembl:
ENSG00000187848
UniProt:
Q9UBL9
OMIM:
600844
Synonyms:
DFNA41, P2X2

Cilia effects upon perturbation of P2RX2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased exploration in new environment, decreased locomotor activity, decreased circulating glucose level
Mouse ciliopathy phenotype:
small testis
Human ciliopathy phenotype:
autosomal dominant nonsyndromic hearing loss

Subcellular localization

flagella, lysosomes, nucleus

Functional category

  • Metabolism
  • Reproduction & sperm
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

P2X2 channels are localized to the sperm midpiece, where ATP activation of these channels increases Ca2+ influx (21831833).