PAM

peptidylglycine alpha-amidating monooxygenase

Ensembl:
ENSG00000145730
UniProt:
P19021
OMIM:
170270
Synonyms:
PAL, PAM-1, PHM

Cilia effects upon perturbation of PAM

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased circulating fructosamine level, preweaning lethality, complete penetrance

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

PAM also regulates ciliogenesis in vertebrates, pla ria and chlorophyte algae, and is required for the stability of actin-based microvilli(30879092).

Model organism evidence

C. elegans (1 reference)

Studies in multiple species - from the nematode Caenorhabditis elegans and the chlorophyte alga Chlamydomonas reinhardtii to mammals - have revealed that cilia shed bioactive EVs (ciliary EVs or ectosomes) by outward budding of the ciliary membrane.

PMIDs: 35346578