PAM

peptidylglycine alpha-amidating monooxygenase

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000145730
UniProt:: P19021
OMIM:: 170270
Synonyms:: PAL, PAM-1, PHM

Cilia effects upon perturbation of PAM

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased circulating fructosamine level, preweaning lethality, complete penetrance

Subcellular localization

cilia

References: PMID:30879092, PMID:28513435

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

PAM also regulates ciliogenesis in vertebrates, pla ria and chlorophyte algae, and is required for the stability of actin-based microvilli(30879092).

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