PAQR5

progestin and adipoQ receptor family member 5

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000137819
UniProt:
Q9NXK6
OMIM:
607781
Synonyms:
FLJ20190, MPRG

Cilia effects upon perturbation of PAQR5

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased circulating calcium level

Subcellular localization

basal body

References: PMID:19715581

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Also involved in progesterone signaling, maybe controlling cilia stability or motility (19715581).