PAQR8
progestin and adipoQ receptor family member 8
- Ensembl:
- ENSG00000170915
- UniProt:
- Q8TEZ7
- OMIM:
- 607780
- Synonyms:
- C6ORF33, LMPB1, MPRB
Cilia effects upon perturbation of PAQR8
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=401, lfc=-2.32) PMID:30270045
Phenotypes
- Mouse phenotype:
- abnormal epididymis morphology, enlarged epididymis
Subcellular localization
cilia, lysosomes
Functional category
- Ciliary assembly/disassembly
- Reproduction & sperm
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Likely mediates rapid progesterone sig ling at the cilia(19715581).