PARD3

Cilia effects upon perturbation of PARD3

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Overexpression effect:

Unknown

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.16) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cilia, cytosol

References: PMID:15324661, PMID:18070914, PMID:25144710, PMID:20138861

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Also called PAR3. Interacts with Par6 and aPKC to form a polarity complex that regulates the stability of the ciliary axoneme (15324661). It is required for the elongation of primary cilia, possibly by facilitating anterograde transport of cargo. Interacts with Kif3a, anterograde motor for IFT (18070914, 25144710). PAR3 is also required for apical localisation of centrosome and may also be involved in the proper orientation of the axoneme (20138861).