PARD6A

par-6 family cell polarity regulator alpha

Ensembl:
ENSG00000102981
UniProt:
Q9NPB6
OMIM:
607484
Synonyms:
PAR-6, PAR-6A, PAR6ALPHA, TAX40, TIP-40

Cilia effects upon perturbation of PARD6A

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
impaired glucose tolerance

Subcellular localization

basal body, cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Interacts with Par3 and aPKC to form a polarity complex that regulates the stability of the ciliary axoneme (15324661)