PARK7
Parkinsonism associated deglycase
- Ensembl:
- ENSG00000116288
- UniProt:
- Q99497
- OMIM:
- 602533
- Synonyms:
- DJ-1, DJ1, GATD2
Cilia effects upon perturbation of PARK7
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- abnormal head morphology, increased circulating hdl cholesterol level, increased circulating serum albumin level, decreased bone mineral density
Subcellular localization
cytosol, flagella, mitochondria, nucleus
Functional category
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
PARK7 localized to flagella (25613900)