PAWR

pro-apoptotic WT1 regulator

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000177425
UniProt:
Q96IZ0
OMIM:
601936
Synonyms:
PAR-4, PAR4

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased locomotor activity, decreased circulating creatinine level, preweaning lethality, incomplete penetrance

Subcellular localization

cilia, nucleus, ciliary tip

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion

Function

PAWR has localized in cilia.