PAX7

paired box 7

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000009709
UniProt:: P23759
OMIM:: 167410
Synonyms:: HUP1

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.14) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.35, ciliated=55.7%) PMID:26595381

Phenotypes

Mouse phenotype:: decreased circulating triglyceride level, preweaning lethality, complete penetrance, preweaning lethality, incomplete penetrance

Subcellular localization

nucleus

References: PMID:35671424

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Cardiac & muscle development

Function

Myf5-Arl3-/- mice develop grossly the same as WT mice. Intriguingly, mechanical stimulation-induced muscle hypertrophy or myoblast differentiation is abrogated in Myf5-Arl3-/- and Pax7-Arl3-/- mice or primary isolated Myf5-Arl3-/- and Pax7-Ift88-/- myoblasts, likely due to defective cilia-mediated Hedgehog (Hh) signaling ( 35671424).

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