PCDHB16

protocadherin beta 16

Ensembl:
ENSG00000291684, ENSG00000272674
UniProt:
Q9NRJ7
OMIM:
606345
Synonyms:
KIAA1621, ME1, PCDH-BETA16, PCDH3X, PCDHB8A

Cilia effects upon perturbation of PCDHB16

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Pcdhb16 is in connecting cilia and outer segment disks of photoreceptors(18279309).

Model organism evidence

Mus musculus (2 references)

CAPZA1 deficiency disrupts sperm flagellar structure and motility, potentially involving the p300/SLC7A11 pathway.

STUDY QUESTION: Does DNAH14 deficiency impair sperm flagellar integrity and contribute to male infertility?

PMIDs: 41858859, 41686705