PCNA

proliferating cell nuclear antigen

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000132646
UniProt:
P12004
OMIM:
176740

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-14.42) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Ataxia-Telangiectasia-like Disorder

References: PMID:24911150, PMID:33426167, PMID:36990216, PMID:37511614

Subcellular localization

centrosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Transcription regulation

Function

Mutations in the PCNA gene cause Ataxia-telangiectasia-like Disorder (PMID: 24911150).