PCNA
proliferating cell nuclear antigen
- Ensembl:
- ENSG00000132646
- UniProt:
- P12004
- OMIM:
- 176740
Cilia effects upon perturbation of PCNA
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-14.42) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Ciliopathy associations
- Ataxia-Telangiectasia-like Disorder
Subcellular localization
centrosome, cilia associated gene, nucleus
Functional category
- Ciliary assembly/disassembly
- Transcription regulation
Function
Mutations in the PCNA gene cause Ataxia-telangiectasia-like Disorder (PMID: 24911150).
Model organism evidence
Mus musculus (2 references)
Primary cilia morphology (immunofluorescence), Shh signaling components (Smo, Gli3 via qPCR/Western blot), and proliferation markers (CCK-8 assay, Proliferating Cell Nuclear Antigen [PCNA], Cyclin D1) were analyzed.
This gene expresses a component of the axonemal dynein complex that functions in cilia or flagella.