PDCD6

programmed cell death 6

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000249915
UniProt:
O75340
OMIM:
601057
Synonyms:
ALG-2, PEF1B

Cilia effects upon perturbation of PDCD6

Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

References: PMID:27866888

Functional category

  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ESCRT-related protein (PDCD6) might mediate ectosome release and thereby influence flagellar shortening in Chlamydomonas(27866888).