PDE11A

phosphodiesterase 11A

Ensembl:
ENSG00000128655
UniProt:
Q9HCR9
OMIM:
604961

Cilia effects upon perturbation of PDE11A

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal eye morphology, increased vertical activity, abnormal ovary morphology
Mouse ciliopathy phenotype:
microphthalmia, small testis, abnormal uterus morphology, hydrometra, abnormal testis morphology

Subcellular localization

basal body, cilia, cytosol

Functional category

  • Ciliary assembly/disassembly

Function

PDE11A has localized in basal body.