PDE4C

phosphodiesterase 4C

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000105650
UniProt:: Q08493
OMIM:: 600128
Synonyms:: DPDE1, PDE21

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.55) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: hyperactivity, decreased grip strength, decreased startle reflex

Subcellular localization

cilia, cytosol, basal body

References: PMID:41005307, PMID:21670265

Functional category

Ciliary assembly/disassembly

Function

Catabolizes cAMP, located in renal primary cilia. Component of the AKAP150 complex, it promotes the hydrolysis of cAMP to negatively regulate cAMP signaling (21670265).

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