PDE4C

phosphodiesterase 4C

Ensembl:
ENSG00000105650
UniProt:
Q08493
OMIM:
600128
Synonyms:
DPDE1, PDE21

Cilia effects upon perturbation of PDE4C

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.55) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity, decreased grip strength, decreased startle reflex

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly

Function

Catabolizes cAMP, located in re l primary cilia. Component of the AKAP150 complex, it promotes the hydrolysis of cAMP to negatively regulate cAMP sig ling (21670265).