PDE5A

phosphodiesterase 5A

Ensembl:
ENSG00000138735
UniProt:
O76074
OMIM:
603310

Cilia effects upon perturbation of PDE5A

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased body length, small liver, abnormal caudal vertebrae morphology
Mouse ciliopathy phenotype:
abnormal liver morphology

Subcellular localization

basal body, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

PDE5A has localized in basal body.