PDGFA

platelet derived growth factor subunit A

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000197461
UniProt:: P04085
OMIM:: 173430
Synonyms:: PDGF-A, PDGF1

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:16243034

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

PDGF-AA activates PDGFRα in the primary cilium of NIH 3T3 fibroblasts, followed by mitogenic signaling through Akt and the Mek1/2-Erk1/2 pathway(16243034).

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