PDGFA

platelet derived growth factor subunit A

Ensembl:
ENSG00000197461
UniProt:
P04085
OMIM:
173430
Synonyms:
PDGF-A, PDGF1

Cilia effects upon perturbation of PDGFA

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PDGF-AA activates PDGFR伪 in the primary cilium of NIH 3T3 fibroblasts, followed by mitogenic sig ling through Akt and the Mek1/2-Erk1/2 pathway(16243034).

Model organism evidence

Mus musculus (1 reference)

Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers.

PMIDs: 36623505