PDLIM3

PDZ and LIM domain 3

Ensembl:: ENSG00000154553
UniProt:: Q53GG5
OMIM:: 605889
Synonyms:: ALP

Cilia effects upon perturbation of PDLIM3

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

PDLIM3 is required for SHH pathway activation in MB cells. PDLIM3 can bind with cholesterol via the PDZ domain , PDLIM3 localizes in primary cilia and promotes ciliogenesis by tethering cholesterol in the cilium(36813922).

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