PEBP1

phosphatidylethanolamine binding protein 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000089220
UniProt:: P30086
OMIM:: 604591
Synonyms:: HCNP, PBP, PEBP, RKIP

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-17.24) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, nucleus

References: PMID:21685394, PMID:31960115

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Rkip (Raf-1 kinase inhibitory protein)prevents cilia formation and is associated with Cep290-mediated photoreceptor degeneration (21685394). PEBP1 (RKIP) localizes to the connecting cilium of photoreceptors, where it interacts with CEP290, and blocks cilia formation through binding RAB8A (PMID 21685394; PMID 31960115).

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