PELI1

pellino E3 ubiquitin protein ligase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000197329
UniProt:
Q96FA3
OMIM:
614797

Cilia effects upon perturbation of PELI1

Loss-of-function effect:
Impairment of ciliary disassembly

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased lean body mass, increased neutrophil cell number, decreased body length, increased spleen weight, abnormal spleen morphology, enlarged spleen, improved glucose tolerance, decreased brain weight

Subcellular localization

cilia, cytosol, nucleus, basal body

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PELI1 has localized in cilia.