PELI1

pellino E3 ubiquitin protein ligase 1

Ensembl:
ENSG00000197329
UniProt:
Q96FA3
OMIM:
614797

Cilia effects upon perturbation of PELI1

Loss-of-function effect:
Impairment of ciliary disassembly

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased lean body mass, increased neutrophil cell number, decreased body length, increased spleen weight, abnormal spleen morphology, enlarged spleen, improved glucose tolerance, decreased brain weight
Mouse ciliopathy phenotype:
enlarged heart

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PELI1 has localized in cilia.