PEX3

Cilia effects upon perturbation of PEX3

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.24) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal eye size; increased bone mineral density; increased bone mineral content; cornea vascularization; process of degenerative change; decreased circulating cholesterol level; abnormal eye morphology; abnormal tail morphology; decreased circulating serum albumin level; abnormal cornea morphology; increased heart weight; decreased body weight; developmental dysplasia; increased lean body mass; decreased circulating total protein level; decreased total body fat amount; decreased circulating LDL cholesterol level; abnormal vertebrae morphology; inflammation; decreased circulating HDL cholesterol level

Subcellular localization

cilia associated gene, nucleoplasm, peroxisome

Functional category

• Ciliary assembly/disassembly

Function

Knockdown of peroxisome biogenesis factor genes (PEX1 or PEX3) partially suppressed ciliogenesis(PMID: 28122914).