PFKM

phosphofructokinase, muscle

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000152556
UniProt:
P08237
OMIM:
610681
Synonyms:
PFK-1, PFKX, PPP1R122

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.11) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal skin morphology, small liver, abnormal semil vesicle morphology, decreased total body fat amount, increased lean body mass, decreased body length, small semil vesicle

Subcellular localization

cytosol, endoplasmic reticulum, flagella

References: PMID:25613900

Functional category

  • Metabolism
  • Reproduction & sperm
  • Cardiac & muscle development

Function

PFKM has localized in flagella.