PFKM

phosphofructokinase, muscle

Ensembl:: ENSG00000152556
UniProt:: P08237
OMIM:: 610681
Synonyms:: PFK-1, PFKX, PPP1R122

Cilia effects upon perturbation of PFKM

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.11) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: abnormal skin morphology, small liver, abnormal semil vesicle morphology, decreased total body fat amount, increased lean body mass, decreased body length, small semil vesicle
Mouse ciliopathy phenotype:: cataract, abnormal liver morphology, enlarged testis, abnormal testis morphology, abnormal vitreous body morphology

Subcellular localization

cytosol, endoplasmic reticulum, flagella

Functional category

Metabolism
Reproduction & sperm
Cardiac & muscle development

Function

PFKM has localized in flagella.

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