PGE2

Cilia effects upon perturbation of PGE2

Overexpression effect:

Longer cilia

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Cilia length regulation

Function

In agreement with animal model studies, cultured mammalian cells deficient in PGE2 signaling also display defective ciliogenesis. The existence of a previously unexplored aspect of human ciliopathies arising from abnormal prostagladin signaling. Addition of exogenous PGE2 increased both cilia length and percentages of ciliated cells in control cells but not in EP4-depleted cells , indicating that EP4 acts downstream of PGE2 signaling during ciliogenesis(25173977).