PGR

progesterone receptor

Ensembl:: ENSG00000082175
UniProt:: P06401
OMIM:: 607311
Synonyms:: NR3C3, PR

Cilia effects upon perturbation of PGR

Overexpression effect:: Increased

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.28) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, microtubules, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Protein processing & maturation
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

PR in ciliated epithelial cells localizes to the lower half of the cilia and not to microvilli, which are positioned at the base between individual cilia (17170211).

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