PGRMC2

progesterone receptor membrane component 2

Ensembl:
ENSG00000164040
UniProt:
O15173
OMIM:
607735
Synonyms:
DG6, PMBP

Cilia effects upon perturbation of PGRMC2

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.55) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)
  • ECM & connective tissue
  • Transcription regulation

Function

BMPR2, PTPRS, and PGRMC2 were involved in cilia formation . Even when cilia were present in these cells, the formation of cELV was significantly abolished in all five (BMPR2, TFRC, F11R, PTPRS, and PGRMC2) knockdown cells (32832346).