PGS1

phosphatidylglycerophosphate synthase 1

Ensembl:
ENSG00000087157
UniProt:
Q32NB8
OMIM:
614942
Synonyms:
DKFZP762M186

Cilia effects upon perturbation of PGS1

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.55) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=215, lfc=0.67) PMID:30270045

Phenotypes

Mouse phenotype:
increased circulating phosphate level, preweaning lethality, complete penetrance

Subcellular localization

flagella, lysosomes, mitochondria

Function

PGS1 has localized in flagella.