PHLPP2

PH domain and leucine rich repeat protein phosphatase 2

Ensembl:
ENSG00000040199
UniProt:
Q6ZVD8
OMIM:
611066
Synonyms:
KIAA0931, PHLPPL, PPM3B

Cilia effects upon perturbation of PHLPP2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.26) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased startle reflex

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

PHLPP2 has localized in primary cilia.