PI4KB

phosphatidylinositol 4-kinase beta

Ensembl:
ENSG00000143393
UniProt:
Q9UBF8
OMIM:
602758
Synonyms:
PI4K-BETA, PI4K92, PIK4CB

Cilia effects upon perturbation of PI4KB

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.63) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Polycystic Kidney Disease

Subcellular localization

cilia associated gene, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mutations in the PI4KB gene cause Polycystic Kidney Disease (PMID: 34469896).

Model organism evidence

Danio rerio (1 reference)

To investigate the developmental role of Pi4kb, especially its function on zebrafish ciliogenesis, we generated pi4kb deletion mutants using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 technique.

PMIDs: 33358778