PI4KB

phosphatidylinositol 4-kinase beta

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000143393
UniProt:
Q9UBF8
OMIM:
602758
Synonyms:
PI4K-BETA, PI4K92, PIK4CB

Cilia effects upon perturbation of PI4KB

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.63) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Polycystic Kidney Disease

References: PMID:34469896

Subcellular localization

cytosol

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mutations in the PI4KB gene cause Polycystic Kidney Disease (PMID: 34469896).