PIDD1

p53-induced death domain protein 1

Ensembl:
ENSG00000177595
UniProt:
Q9HB75
OMIM:
605247
Synonyms:
DKFZP434D229, LRDD, MGC16925, PIDD

Cilia effects upon perturbation of PIDD1

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Human ciliopathy phenotype:
Intellectual disability

Subcellular localization

basal body, lysosomes, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation
  • Transcription regulation

Function

ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification( 33350495).