PIERCE1

piercer of microtubule wall 1

Ensembl:
ENSG00000160345
UniProt:
Q5BN46
OMIM:
614502
Synonyms:
C9ORF116, MGC29761, RBEST47

Cilia effects upon perturbation of PIERCE1

Phenotypes

Mouse phenotype:
increased grip strength

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

CCDC113, CCDC96, C4orf47, CCDC38, C7orf31, CCDC146, CCDC81 and CCDC116 as centrosome-associated proteins(25074808).

Model organism evidence

Mus musculus (1 reference)

The phenotype of Pierce1-null mice most closely resembled that of mutant mice with impaired ciliogenesis and/or ciliary motility of the node.

PMIDs: 27305836