PIEZO1
piezo type mechanosensitive ion channel component 1 (Er blood group)
- Ensembl:
- ENSG00000103335
- UniProt:
- Q92508
- OMIM:
- 611184
- Synonyms:
- FAM38A, KIAA0233
Cilia effects upon perturbation of PIEZO1
- Loss-of-function effect:
- Shorter cilia
- Overexpression effect:
- Increased
Ciliogenesis screen results (2 screens)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.89) PMID:41160700
Phenotypes
- Mouse phenotype:
- decreased locomotor activity, abnormal limb bud morphology, preweaning lethality, complete penetrance, abnormal embryo size, pallor, abnormal placenta size, pale yolk sac, embryonic growth retardation
- Mouse ciliopathy phenotype:
- increased circulating alanine transamise level, abnormal uriry bladder morphology
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
Function
Piezo1 co-localized with primary cilia in mandibular condyle chondrocytes (35279604).
Model organism evidence
Mus musculus (1 reference)
PIEZO1-Primary Cilia Axis Mediates Compressive Stress-Induced Growth Plate Degeneration and Ossification in Adolescent Idiopathic Scoliosis.
PMIDs: 41194970