PIK3AP1

phosphoinositide-3-kinase adaptor protein 1

Ensembl:: ENSG00000155629
UniProt:: Q6ZUJ8
OMIM:: 607942
Synonyms:: BCAP, FLJ35564

Cilia effects upon perturbation of PIK3AP1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.37) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased neutrophil cell number, increased monocyte cell number, decreased lymphocyte cell number, abnormal cholesterol homeostasis

Subcellular localization

basal body, cytosol

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

PIK3AP1, aslo known as BCAP. Centriolar satellite protein that plays a role as negative regulator of ciliogenesis, specifically initiation (28775150).

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