PIK3CD

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Ensembl:
ENSG00000171608
UniProt:
O00329
OMIM:
602839
Synonyms:
P110D

Cilia effects upon perturbation of PIK3CD

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.01) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.90) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
Combined immunodeficiency with facio-oculo-skeletal anomalies; combined immunodeficiency with faciooculoskeletal anomalies

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PIK3CD has localized in ciliary tip, primary cilia.