PIK3R3

phosphoinositide-3-kinase regulatory subunit 3

Ensembl:
ENSG00000117461
UniProt:
Q92569
OMIM:
606076
Synonyms:
P55

Cilia effects upon perturbation of PIK3R3

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.37) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.69, ciliated=58.3%) PMID:26595381

Subcellular localization

cytosol, flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

PIK3R3 has localized in flagella.