PINK1

PTEN induced kinase 1

Ensembl:
ENSG00000158828
UniProt:
Q9BXM7
OMIM:
608309
Synonyms:
BRPK, PARK6

Cilia effects upon perturbation of PINK1

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased bone mineral content, decreased mean platelet volume, decreased bone mineral density

Subcellular localization

cilia associated gene, cytosol, mitochondria, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Transcription regulation

Function

Shortening of primary cilia in PINK1-deficient human cellular and mouse models of familial PD ( 35974013).