PIP4K2A

phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Ensembl:
ENSG00000150867
UniProt:
P48426
OMIM:
603140
Synonyms:
PIP5K2A, PIP5KIIA, PIP5KIIALPHA

Cilia effects upon perturbation of PIP4K2A

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Decreased

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.15) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis ( 38052787).