PJA2

praja ring finger ubiquitin ligase 2

Ensembl:
ENSG00000198961
UniProt:
O43164
OMIM:
619341
Synonyms:
KIAA0438, NEURODAP1, PRAJA2, RNF131

Cilia effects upon perturbation of PJA2

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.34) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.20) PMID:20393562

Phenotypes

Mouse phenotype:
abnormal spleen morphology, abnormal skin morphology

Subcellular localization

basal body, cilia, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

PJA2 has localized in basal body ,transition zone.

Model organism evidence

Mus musculus (1 reference)

Mechanistic investigation reveals that intraflagellar transport 88 (IFT88), a protein essential for ciliary assembly and maintenance, undergoes UFMylation at lysine 572.

PMIDs: 41272290